Atrialfibrillation(AF)isthemostcommoncardiacarrhythmiainthegeneralpopulation.Itisassociatedwithan increaseinmortalityandmorbidity,suchasstrokeandheartfailure,andislinkedtoreducedqualityoflifeand impaired cognitive functions. The Swiss-AF cohort aims to generate new insights into the interrelationships between AF, structural brainalterationsandcognitivedeclinebasedonalong-termperspective.Thiswillhelptodefinenewsolutionsforthis crucial public health issue. Swiss-AF is funded by the Swiss National Science Foundation (SNSF).